Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory
نویسندگان
چکیده
منابع مشابه
Adult Hippocampal Neurogenesis and Memory
Adult neurogenesis, a concept emergent in the late 1990s, is the generation of new neurons in the adult brain. This process occurs thank to cells who have this proliferative feature, named as Neural Stem Cells (NSCs). Neural Stem Cells (NSCs) are primary progenitors who can generate the two neural types (neurons and glia). Classically it was assumed that NSCs are only present in the embryo, but...
متن کاملAdult Hippocampal Neurogenesis and Memory
Adult neurogenesis, a concept emergent in the late 1990s, is the generation of new neurons in the adult brain. This process occurs thank to cells who have this proliferative feature, named as Neural Stem Cells (NSCs). Neural Stem Cells (NSCs) are primary progenitors who can generate the two neural types (neurons and glia). Classically it was assumed that NSCs are only present in the embryo, but...
متن کاملA model of hippocampal neurogenesis in memory and mood disorders.
The mounting evidence for neurogenesis in the adult hippocampus has fundamentally challenged the traditional view of brain development. The intense search for clues as to the functional significance of the new neurons has uncovered a surprising connection between neurogenesis and depression. In animal models of depression, neurogenesis is reduced, whereas many treatments for depression promote ...
متن کاملNeurogenesis and Hippocampal Memory System
WHEN DISCUSSING A BRAIN FUNCTION SUCH AS MEMORY, one should relate it to brain plasticity. One definition of plasticity is an alternative way of performing the same function. Anecdotal evidence suggests that the human brain can perform amazing memory feats in unexpected, alternative ways. For example, the established ability of savants (individuals with partial brain damage) to memorize events,...
متن کاملAggravation of Chronic Stress Effects on Hippocampal Neurogenesis and Spatial Memory in LPA1 Receptor Knockout Mice
BACKGROUND The lysophosphatidic acid LPA₁ receptor regulates plasticity and neurogenesis in the adult hippocampus. Here, we studied whether absence of the LPA₁ receptor modulated the detrimental effects of chronic stress on hippocampal neurogenesis and spatial memory. METHODOLOGY/PRINCIPAL FINDINGS Male LPA₁-null (NULL) and wild-type (WT) mice were assigned to control or chronic stress condit...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2009
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2009.130